Search results for "oral morphine"

showing 8 items of 8 documents

Fentanyl Pectin Nasal Spray Versus Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A …

2016

Context Fentanyl products have shown superiority over oral opioids for the management of breakthrough cancer pain (BTcP). However, these studies did not use an appropriate patient selection, and drugs have been compared using a different rationale. Objectives The aim of this randomized, crossover, controlled study was to compare the efficacy and safety of fentanyl pectin nasal spray (FPNS) and oral morphine (OM), given in doses proportional to opioid daily doses. Methods Cancer patients with pain receiving ≥60 mg of OM equivalents/day and presenting with ≤3 episodes of BTcP/day were included. Patients received, in a randomized, crossover manner, FPNS or OM at doses proportional to the d…

Malefentanyl pectin nasal spraymedicine.medical_treatmentAdministration OralContext (language use)Fentanyl03 medical and health sciences0302 clinical medicinemedicineHumansCancer painGeneral NursingNursing (all)2901 Nursing (miscellaneous)Pain MeasurementAnalgesicsCross-Over StudiesMorphinebusiness.industryNasal SpraysMiddle Agedbreakthrough painCrossover studyFentanylRegimenTreatment OutcomeAnesthesiology and Pain MedicineOpioidNasal sprayoral morphine030220 oncology & carcinogenesisAnesthesiaMorphinePectinsFemaleNeurology (clinical)businessCancer painbreakthrough pain; Cancer pain; fentanyl pectin nasal spray; oral morphine; Nursing (all)2901 Nursing (miscellaneous); Neurology (clinical); Anesthesiology and Pain Medicine030217 neurology & neurosurgerymedicine.drug
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Slow release oral morphine versus methadone for the treatment of opioid use disorder

2019

ObjectiveTo assess the efficacy of slow release oral morphine (SROM) as a treatment for opioid use disorder (OUD).DesignSystematic review and meta-analysis of randomised controlled trials (RCTs).Data sourcesThree electronic databases were searched through 1 May 2018: the Cochrane Central Register of Controlled Trials, MEDLINE and EMBASE. We also searched the following electronic registers for ongoing trials: ClinicalTrials.gov, WHO International Clinical Trials Registry Platform, Current Controlled Trials and the EU Clinical Trials Register.Eligibility criteria for selecting studiesWe included RCTs of all durations, assessing the effect of SROM on measures of treatment retention, heroin use…

Narcoticsmedicine.medical_specialtyAddictionAdministration OralCraving1681substance use treatmentHeroin03 medical and health sciences0302 clinical medicineSlow release oral morphine (SROM)Internal medicineOpiate Substitution TreatmentHumansMedicine1506030212 general & internal medicine10. No inequalityAdverse effectRandomized Controlled Trials as TopicMorphinebusiness.industryResearchsubstance misuseopioid use disorderOpioid use disorderGeneral MedicineOpioid-Related Disordersmedicine.disease3. Good healthmeta-analysisClinical trialoral morphineOpioid use disorderReducing heroin useDelayed-Action PreparationsMeta-analysisRelative riskmedicine.symptombusinessMethadone030217 neurology & neurosurgerymedicine.drugMethadoneBMJ Open
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Equipotent doses to switch from high doses of opioids to transdermal buprenorphine.

2008

INTRODUCTION: The aim of this study was to evaluate the equianalgesic ratio of transdermal buprenorphine (TD BUP) with oral morphine and TD fentanyl in a sample of consecutive cancer patients receiving stable doses of 120-240 mg of oral morphine or 50-100 microg of TD fentanyl, reporting adequate pain and symptom control. MATERIALS, METHODS, AND RESULTS: Patients receiving daily stable doses of opioids for more than 6 days, with no more than two doses of oral morphine (20 and 40 mg, respectively) as needed, were switched to TD BUP using a fentanyl-BUP ratio of 0.6:0.8 and an oral morphine-BUP ratio of 70:1. Opioid doses, pain and symptom intensity, global satisfaction, and number of breakth…

Maletransdermal buprenorphinePainAdministration CutaneousFentanylNeoplasmsHigh dosesMedicineHumansSymptom controlProspective StudiesOral morphineAgedDose-Response Relationship Drugbusiness.industryMiddle AgedEquianalgesicBuprenorphineAnalgesics OpioidFentanylOncologyPatient SatisfactionAnesthesiaFemaleTransdermal Buprenorphinehigh doses of opioidsbusinessCancer painmedicine.drugSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
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Meaningful cut-off pain intensity for breakthrough pain changes in advanced cancer patients

2013

Abstract OBJECTIVES: To assess the level of pain intensity at which patients feel the impetus to ask for a breakthrough cancer pain (BTcP) medication, and level of pain intensity at which patients consider they have achieved acceptable pain control after receiving a BTcP medication. METHODS: A consecutive sample of patients who were receiving oral morphine equivalents equal to or more than 60 mg daily, and were prescribed rapid onset opioids for the management of episodes of BTcP, were included in the study. Focused educational activities regarding BTcP and numerical scales were established during hospital admission. At discharge patients were interviewed to find out what was the pain inten…

Malemedicine.medical_specialtyCoping (psychology)Palliative careBreakthrough PainPainSettore MED/42 - Igiene Generale E ApplicataCONSECUTIVE SAMPLEadvanced cancer patientNeoplasmsHumansPain ManagementMedicineOral morphineAgedPain MeasurementMorphinebusiness.industrybreakthrough pain; advanced cancer patients; epidemiologic studyGeneral MedicineMiddle Agedbreakthrough painAdvanced cancerAnalgesics OpioidClinical trialepidemiologic studyPhysical therapyFemalebusinessCancer pain
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Fentanyl Buccal Tablet vs. Oral Morphine in Doses Proportional to the Basal Opioid Regimen for the Management of Breakthrough Cancer Pain: A Randomiz…

2015

Fentanyl products have shown superiority to oral opioids for the management of breakthrough cancer pain (BTcP). However, these studies did not use appropriate patient selection, and drugs have been compared by using different rationales.The aim of this randomized, crossover, controlled study was to compare efficacy and safety of fentanyl buccal tablets (FBTs) and oral morphine (OM), given in doses proportional to opioid daily doses.Cancer patients with pain receiving ≥60 mg or more of oral morphine equivalents per day and presenting with ≤3 episodes of BTcP per day were included. In a randomized, crossover manner, patients received FBT or OM at doses proportional to the daily opioid regimen…

Malefentanyl buccal tabletContext (language use)FentanylNeoplasmsmedicineHumansCancer painGeneral NursingNursing (all)2901 Nursing (miscellaneous)Pain MeasurementCross-Over StudiesMorphinebusiness.industrybreakthrough pain; Cancer pain; fentanyl buccal tablet; oral morphine; Anesthesiology and Pain Medicine; Neurology (clinical); Nursing (all)2901 Nursing (miscellaneous)Administration BuccalPatient PreferenceBuccal administrationMiddle Agedbreakthrough painCrossover studyAnalgesics OpioidFentanylRegimenTreatment OutcomeAnesthesiology and Pain MedicineOpioidoral morphineAnesthesiaMorphineFemaleNeurology (clinical)Cancer painbusinessmedicine.drug
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Maintenance treatment for opioid dependence with slow‐release oral morphine: a randomized cross‐over, non‐inferiority study versus methadone

2012

Aims To compare the efficacy of slow-release oral morphine (SROM) and methadone as maintenance medication for opioid dependence in patients previously treated with methadone. Design Prospective, multiple-dose, open label, randomized, non-inferiority, cross-over study over two 11-week periods. Methadone treatment was switched to SROM with flexible dosing and vice versa according to period and sequence of treatment. Setting Fourteen out-patient addiction treatment centres in Switzerland and Germany. Participants Adults with opioid dependence in methadone maintenance programmes (dose ≥50 mg/day) for ≥26 weeks. Measurements The efficacy end-point was the proportion of heroin-positive urine samp…

AdultMaleNarcoticsMethadone maintenanceretention ratePopulationslow-release oral morphineAdministration OralMedicine (miscellaneous)Maintenance ChemotherapyMedication AdherencemethadoneOpiate Substitution TreatmentmedicineHumanseducationMorphine Derivativeseducation.field_of_studyCross-Over StudiesMorphinemaintenance treatmentCodeinebusiness.industryCodeineResearch ReportsOpioid use disorderOpiate Substitution TreatmentMiddle AgedOpioid-Related Disordersmedicine.diseaseCrossover studyPsychiatry and Mental healthTreatment OutcomeOpioidDelayed-Action PreparationsAnesthesiaFemaleDose–responsebusinessopioid addictionMethadonemedicine.drugAddiction
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The prevalence and characteristics of breakthrough cancer pain in patients receiving low doses of opioids for background pain

2021

Simple Summary The aim of this study was to assess the prevalence and characteristics of breakthrough cancer pain (BTcP) in patients receiving low doses of opioids for background pain. This prospective study showed that in this population, BTcP prevalence was 69.8%. Many patients did not achieve a sufficient level of satisfaction with BTcP medications, particularly with oral morphine. Data also suggest that better optimization of background analgesia, though apparently acceptable, may limit the number of BTcP episodes. Abstract The aim of this study was to assess the prevalence and characteristics of breakthrough cancer pain (BTcP) in patients receiving low doses of opioids for background p…

Cancer Researchmedicine.medical_specialtyPain relieflcsh:RC254-282ArticleCONSECUTIVE SAMPLE03 medical and health sciences0302 clinical medicineAnalgesic therapyInternal medicineEpidemiologymedicineIn patientOral morphinebreakthrough cancer pain; opioids; dosesbusiness.industryLow doseBreakthrough cancer painlcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogensdosesOpioidsOncologyDose030220 oncology & carcinogenesisCancer painbusiness030217 neurology & neurosurgery
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Safety and tolerability of slow-release oral morphine versus methadone in the treatment of opioid dependence

2014

Opioid substitution treatment (OST) for opioid dependence may be limited by adverse events (AEs). Increasing the range of therapeutic options optimizes outcomes and facilitates patient management. An international, multi-center, two-phase study investigated the efficacy and safety of slow-release oral morphine (SROM) versus methadone in patients receiving methadone therapy for opioid dependence. In phase 1 (two way cross-over, 11 weeks each period) patients were randomized to SROM or methadone oral solution. In phase 2 (25 weeks), patients continued treatment with SROM (group A) or switched from methadone to SROM (group B). In total, 211 out of 276 completed phase 1 and 198 entered phase 2 …

AdultMaleInternational CooperationAdministration OralMedicine (miscellaneous)QT intervalHeroinOpiate Substitution TreatmentHumansMedicineIn patientOral morphineAdverse effectCross-Over StudiesMorphinebusiness.industryOpioid-Related DisordersEuropePsychiatry and Mental healthClinical PsychologyTreatment OutcomeOpioidTolerabilityDelayed-Action PreparationsAnesthesiaFemalePshychiatric Mental HealthbusinessMethadonemedicine.drugMethadoneJournal of Substance Abuse Treatment
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